Cerebrotendinous Xanthomatosis represents a rare and underdiagnosed inherited neurometabolic disorder due to homozygous or compound heterozygous variants involving the CYP27A1 gene.This bile acid metabolism disorder represents a key potentially treatable neurogenetic condition due to the wide spectrum of neurological presentations in which it most
Assessment of magnetic resonance imaging (MRI) after neoadjuvant chemoradiation therapy (nCRT) is essential in rectal cancer staging and treatment planning.However, when predicting the pathologic complete response (pCR) after nCRT for rectal cancer, existing works either rely on simple quantitative evaluation based on radiomics features or partiall
Ever since Varela and Maturana proposed the concept of autopoiesis as the minimal requirement for life, there has been a focus electric swingarm lenses on cellular systems that erect topological boundaries to separate themselves from their surrounding environment.Here, we reconsider whether the existence of such a spatial boundary is strictly neces
In developing sensory systems, elaborate morphological connectivity between peripheral cells and first-order central neurons emerges via genetic programming before the onset of sensory activities.However, how the first-order central neurons acquire the capacity to interface with peripheral cells remains elusive.By making patch-clamp recordings from
Morenike O Folayan1,2 Bridget G Haire3 Brandon Brown4 1Institute of Public Health, 2Department of Child Dental Health, Obafemi Awolowo University, Ile-Ife, Nigeria; 3Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, NSW, Australia; 4Center for Healthy Communities, Department of Social Medicine a